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7 gram/m(2)) ORALLY times one dose followed by a maintenance dose of 40mg/kg/day (or probalan 1 . 2 grams/m(2)) ORALLY in 4 equally divided doses up to a maximum of 500mg/dose ¾ Gonorrhea therapy with penicillin or ampicillin: (children 2 – 14 yr greater than 50kg) give adult dose Dose Adjustments: ¾ renal impairment: CrCl less than 50mL/min, not recommended ¾ renal impairment: CrCl greater than 50mL/min, no dosage adjustment ¾ FDA labeled indications Gonorrhea therapy with penicillin or ampicillin Contraindications ¾ acute attack – should initiate after acute attack ¾ blood dyscrasias ¾ children under 2 yrs of age ¾ coadministration of salicylates ¾ uric acid kidney stones ¾ hypersensitivity to probenecid ¾ peptic ulcer disease ¾ renal impairment – CrCl less than 50mL/min GI distress, nausea, vomiting, anorexia acute gout attacks blood dyscrasias, aplastic anemia, leukopenia, neutropenia thrombocytopenia hepatic necrosis probalan (rare) nephrotic syndrome (rare) Drug Interactions ¾ bismuth subsalicylate ¾ choline salicylate ¾ magnesium salicylate ¾ sodium salicylate ¾ sodium thiosalicylate Pregnancy Category ¾ caution: kidney disease/peptic ulcers/porphyria/cancer; MAX 2-3g/day ©1974-2003 Thomson MICROMEDEX . Increase serum level and duration of action of beta-lactam antibiotics (penicillin, cephalosporin) Competitively inhibit renal tubular secretion of the antibiotics Well absorbed (>90%), maximal effects on penicillin levels after 2 hours, half-life 3-17 hours Contraindications Hypersensitivity to probenecid Children <2 years High dose aspirin therapy Renal impairment (Clcr<50mL/min) Blood dyscrasias Uric acid kidney stones G-6-PD Deficiency Peptic Ulcer Disease Single dose 25mg/kg (maximum 1g), in multiples of 125mg Administer 15 – 30 minutes prior to IV administration Take with food to minimize GI effects Recommended dose for children over 2 years Dose in 500 mg tablets Cardiovascular: Flushing CNS: Dizziness, headache Dermatologic (2-4%): Rash GI (2%): Anorexia, nausea, vomiting, sore gums Genitourinary: Urinary frequency Hematologic: Anemia, leukopenia, aplastic anemia, hemolytic anemia Hepatic: hepatic necrosis Renal: Nephrotic syndrome, renal colic, uric acid stones Miscellaneous: Hypersensitivity reactions Drug Interactions (see complete list) Antagonize effect of probenecid Antagonize effect of concomitant drug Increase serum concentration, prolong effects *Benzodiazepines (lorazepam, midazolam) Increase serum concentration, significant adverse effects DrugPoints™ System Common Tradenames (See Complete Tradename Listing) Dosage, Adult (usual) ¾ Gonorrhea therapy with penicillin or probalan ampicillin: 2 grams/day ORALLY in ¾ Gonorrhea therapy with penicillin or ampicillin: 1 gram ORALLY just prior to parenteral penicillin or simultaneously with oral ampicillin ¾ Hyperuricemia – initial dose: 250mg ORALLY twice daily for 1 wk ¾ Hyperuricemia – maintenance dose: 500mg ORALLY twice daily Dosage, Pediatric (usual) ¾ Gonorrhea therapy with penicillin or ampicillin: (2 – 14 yr, less than 50kg) initial: 25mg/kg (or 0 .
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